Carnitine Transporter

Met stofwisse-ling wordt de aanmaak en de afbraak van stoffen in ons lichaam bedoeld.

Carnitine transporter. Acylcarnitines arise from the conjugations of acyl-coenzyme A CoAs with carnitine for the transport of long-chain fatty acids across the. Carnitineorganic cation transporter OCTN 2 SLC22A5 plays a pivotal role in renal tubular reabsorption of carnitine a vitamin-like compound on apical membranes of proximal tubules but its. Carnitine 4-N-trimethylammonium-3-hydroxybutyric acid a compound necessary for a transfer of fatty acids for their oxidation within the cell accumulates in brain although beta-oxidation of fatty acids is very low in neurons.

The lowest total carnitine levels are found in PCD 0 to 5 μM normal 25 to 50 μM where the defective plasma membrane carnitine transporter expressed in the muscle heart kidney and skin fibroblasts leads to severe urinary carnitine loss. Carnitine accumulates to lower extent in the brain than in. No other transporter in L.

Grigat S1 Fork C Bach M Golz S Geerts A Schömig E Gründemann D. Indeed this gene was suggested by Zhu et al. The transporter catalyzing carnitine uptake had not been described yet but close to cntAB is a gene aci01347 encoding a potential transporter of the betainecholinecarnitine transporter BCCT family.

De afbraak van vetten in het lichaam. 3 H-carnitine uptake was inhibited by Acetyl-carnitine but not by Asn Gln and Arg thus excluding interference by ATB 0 an amino acid transporter which also recognizes carnitine. Regulates lateral root development.

Lesson on the Carnitine Shuttle. Het lichaam verbrandt vetten om energie uit vrij te maken. OCTN2 is a widely expressed organic cation transporter.

Carnitine is an important metabolite derived from our diet or biosynthesized from lysine and methionine. We discovered a novel carnitine transporter CT2 specifically located in human testis. It plays a key role in the oral absorption tissue distribution and renal reabsorption of L-carnitine.